Neuronatin gene: Imprinted and misfolded
نویسندگان
چکیده
منابع مشابه
Peg5/Neuronatin is an imprinted gene located on sub-distal chromosome 2 in the mouse.
We have established a systematic screen for imprinted genes using a subtraction-hybridization method with day 8.5 fertilized and parthenogenetic embryos. Two novel imprinted genes, Peg1/Mest and Peg3, were identified previously by this method, along with the two known imprinted genes, Igf2 and Snrpn. Recently three additional candidate imprinted genes, Peg5-7 , were detected and Peg5 is analyze...
متن کاملImprinted expression of neuronatin from modified BAC transgenes reveals regulation by distinct and distant enhancers.
Neuronatin (Nnat) is an imprinted gene that is expressed exclusively from the paternal allele while the maternal allele is silent and methylated. The Nnat locus exhibits some unique features compared with other imprinted domains. Unlike the majority of imprinted genes, which are organised in clusters and coordinately regulated, Nnat does not appear to be closely linked to other imprinted genes....
متن کاملMolecular Characterization of the Neuronatin Gene in the Porcine Placenta
Imprinted genes play important roles in placental and embryonic development. Neuronatin (NNAT), first identified as an imprinted gene in human and mouse brains, played important roles in neuronal differentiation in the brain and in glucose-mediated insulin secretion in pancreatic β cells. In the pig, NNAT was reported to be imprinted in eleven tissues. Our previous microarray hybridization stud...
متن کاملSnapShot: Imprinted Gene Clusters
The majority of imprinted genes are found in conserved clusters in the mammalian genome. Shown are mouse imprinted genes that are part of larger imprinting clusters (variations in hum cluster has a prominent gene indicated in the left most column and one or more noncoding (nc)RNAs, which in many cases are critical for the domain-wide regulation of the cluster. A associated imprinted genes that ...
متن کاملThe Human Retinoblastoma Gene Is Imprinted
Genomic imprinting is an epigenetic process leading to parent-of-origin-specific DNA methylation and gene expression. To date, approximately 60 imprinted human genes are known. Based on genome-wide methylation analysis of a patient with multiple imprinting defects, we have identified a differentially methylated CpG island in intron 2 of the retinoblastoma (RB1) gene on chromosome 13. The CpG is...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genomics
سال: 2014
ISSN: 0888-7543
DOI: 10.1016/j.ygeno.2013.12.001